MR1 antigen presentation to MAIT cells and other MR1-restricted T cells

Hamish EG McWilliam; Jose A Villadangos

Journal article

MR1 antigen presentation to MAIT cells and other MR1-restricted T cells

Hamish EG McWilliam, Jose A Villadangos

Nature Reviews Immunology | Nature Research | Published : 2024

DOI: 10.1038/s41577-023-00934-1

Download PDF

Abstract

MHC antigen presentation plays a fundamental role in adaptive and semi-invariant T cell immunity. Distinct MHC molecules bind antigens that differ in chemical structure, origin and location and present them to specialized T cells. MHC class I-related protein 1 (MR1) presents a range of small molecule antigens to MR1-restricted T (MR1T) lymphocytes. The best studied MR1 ligands are derived from microbial metabolism and are recognized by a major class of MR1T cells known as mucosal-associated invariant T (MAIT) cells. Here, we describe the MR1 antigen presentation pathway: the known types of antigens presented by MR1, the location where MR1-antigen complexes form, the route followed by the com..

View full abstract

University of Melbourne Researchers

Hamish McWilliam Author

Jose Villadangos Author

Related Projects (3)

DENDRITIC CELLS AND ANTIGEN PRESENTATION

José Villadangos studies the cells and molecules involved in Antigen Presentation. This phenomenon consists of the detection, capture and di..

ANTIGEN PRESENTATION, RECOGNITION AND THE IMMUNE RESPONSE

This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of technique..

A novel mechanism for pathogen detection highly conserved in mammals

This project aims to delineate biochemically how mammals fight pathogens by alerting their immune system to Vitamin B compounds produced by ..

Grants

Awarded by H.E.G.M. discloses support for the research of this work from the National Health and Medical Research Council of Australia (NHMRC) (2003192). J.A.V. discloses support for the research of this work from the Australian Research Council (ARC) (DP170102471),

Awarded by National Health and Medical Research Council of Australia (NHMRC)

Awarded by Australian Research Council (ARC)

Awarded by NHMRC

Funding Acknowledgements

H.E.G.M. discloses support for the research of this work from the National Health and Medical Research Council of Australia (NHMRC) (2003192). J.A.V. discloses support for the research of this work from the Australian Research Council (ARC) (DP170102471), the NHMRC (1113293 and 1058193) and the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH) (R01AI148407).